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Accession number;03A0237825
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| Title;Antifungal Effect of Various Antifungal Agents on Trichophyton Infection in an in vivo Guinea Pig Model and an in vitro Susceptibility Test. |
| Author;
TSUNODA HIDENOBU
(Aichiidai I Biseibutsumen'ekigaku)
YOKOCHI TAKASHI
(Aichiidai I Biseibutsumen'ekigaku)
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Journal Title;Clinical Pharmacology and Therapy
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Journal Code:L1701A
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ISSN:0917-3994
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VOL.13;NO.2;PAGE.137-145(2003)
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| Figure&Table&Reference;FIG.2, TBL.4, REF.12 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The antifungal activities of various antifungal agents on Trichophyton infection was studied with an in vivo infection model using guinea pigs and an in vitro susceptibility test. Butenafine hydrochloride (BTF) exhibited a stronger antifungal activity in guinea pigs infected with Trichophyton mentagrophytes than bifonazole (BFZ). The intensity of the activity was almost the same as that of terbinafine hydrochloride (TBF). BTF also exhibited antifungal activity in the in vitro susceptibility test using freshly isolated Trichophyton strains. BTF might be useful as a powerful antifungal drug for clinical treatment of Trichophyton infection. (author abst.) |
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