Myelofibrosis by the homogeneous peripheral blood stem cell transplantation.

Accession number;03A0083006
Title;Myelofibrosis by the homogeneous peripheral blood stem cell transplantation.
Author; KUBOTA AKIRA (Kokuritsubyoinkyushuiryose Ketsuekinaikabyoririnshokenkyubu) YOKOYAMA TOSHIHIRO (Kokuritsubyoinkyushuiryose Ketsuekinaikabyoririnshokenkyubu) TAKESHITA MORISHIGE (Kokuritsubyoinkyushuiryose Ketsuekinaikabyoririnshokenkyubu) OKAMURA SEIICHI (Kokuritsubyoinkyushuiryose Ketsuekinaikabyoririnshokenkyubu)
Journal Title;Japanese Journal of Clinical and Experimental Medicine
Journal Code:Z0376B
ISSN:0021-4965
VOL.80;NO.1;PAGE.125-127(2003)
Figure&Table&Reference;FIG.4, TBL.1, REF.10
Pub. Country;Japan
Language;Japanese
Abstract;The case was a 50-year-old man, who complained chiefly of the intermittent claudidcation and pancytopenia. The remarkable decrease of the bone-marrow hemopoiesis nest and diffusive fibrillation were recognized by the bone marrow biopsy, and a complicated chromosomal aberration was recognized in the result of analysis of peripheral blood. Moderate lowering signal was recognized in diffusion over thoracic vertebrae and lumbar by the bone marrow MRI, and it was diagnosed as an idiopathic myelofibrosis. Since repeated blood transfusion of thick erythrocyte (E) was required, the homogeneous peripheral blood stem cell transplantation was carried out making an elder sister of HLA perfect coincidence as a donor. Neutrophils increased on 14th day after the transplantation. Numbers of platelet was stabilized, after E was transfused on 46th day after the transplantation. There was no infectious disease which was difficult to control. Though blood transfusion of E was necessary, the progress was good and the case lelft hospital on 60th day after the transplantation.