Factors in Double Cancers of the Esophagus and the Head and Neck
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Accession number;03A0566158
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| Title;Factors in Double Cancers of the Esophagus and the Head and Neck |
| Author;
OKADA RYOSUKE
(Tokyoidai Gekagakudaisan)
OSAKA YOSHIAKI
(Tokyoidai Gekagakudaisan)
TAKAGI YU
(Tokyoidai Gekagakudaisan)
SATO SHIGERU
(Tokyoidai Gekagakudaisan)
AOKI TATSUYA
(Tokyoidai Gekagakudaisan)
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Journal Title;Journal of the Japan Broncho-Esophagological Society
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Journal Code:Z0674A
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ISSN:0029-0645
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VOL.54;NO.4;PAGE.285-290(2003)
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| Figure&Table&Reference;TBL.4, REF.20 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;It is well known that there are many cases of double cancers of the esophagus and the head and neck, but the factors behind this overlapping have not yet been adequately elucidated. In our study, we drew comparisons with cases of esophageal cancer alone in order to determine whether the Brinkman index (BI), the sake index (SI), human papilloma virus (HPV), cancer-related genes (p53,pRb,p16) and aldehyde dehydrogenase 2 (ALDH2) contribute to the genesis of double cancers of the esophagus and the head and neck. It was found that in double cancer cases, the correlation of BI, SI and multiple cancers of the esophagus were significant in magnitude (p<0.01). No significant differences could be noted, however, for the HPV positive rate or in the expression of p53, pRb or p16. ALDH2 gene deficiency was recognized in 26 cases (78.8%) of the double cancers we studied and in 17 cases (53.1%) of esophageal cancer alone. The rate was thus significantly higher in double cancer cases (p<0.05). From these findings, it can be suggested that cigarette smoking, alcohol consumption and ALDH2 gene deficiency are all closely related to the genesis of double cancers of the esophagus and the head and neck. (author abst.) |
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