Reduction of Postoperative Adhesions by N,O-Carboxymethylchitosan and Spermine NONOate in Rats.
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Accession number;03A0583403
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| Title;Reduction of Postoperative Adhesions by N,O-Carboxymethylchitosan and Spermine NONOate in Rats. |
| Author;
DURAN B
(Cumhuriyet Univ. School Of Medicine, Sivas, Tur)
AK D
(Cumhuriyet Univ. School Of Medicine, Sivas, Tur)
CETIN A
(Cumhuriyet Univ. School Of Medicine, Sivas, Tur)
GUVENAL T
(Cumhuriyet Univ. School Of Medicine, Sivas, Tur)
CETIN M
(Cumhuriyet Univ. School Of Medicine, Sivas, Tur)
IMIR A G
(Cumhuriyet Univ. School Of Medicine, Sivas, Tur)
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Journal Title;Exp Anim
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Journal Code:Z0755A
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ISSN:1341-1357
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VOL.52;NO.4;PAGE.267-272(2003)
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| Figure&Table&Reference;FIG.2, REF.25 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Background: Postsurgical adhesions can occur following virtually all types of surgery, resulting in serious clinical complications. Therefore, prevention of adhesions is an important goal of surgical practice. A rat uterine horn model was used to investigate the efficacy of N,O-carboxymethylchitosan(NOCC) and spermine NONOate(SPER/NO) alone and in combination in preventing adhesion formation. Methods: Sixty Wistar albino rats underwent bilateral uterine horn injury with a unipolar cautery. Study groups were as follows: (i) control group, no adjuvant therapy; and those with adjuvant applied, (ii) normal saline group, 2ml of normal saline was given; (iii) NOCC group, 2ml of 2% NOCC gel was given; (iv) SPER/NO group, 2ml of SPER/NO(0.5mg/ml) was given, and (v) NOCC plus SPER/NO group, 2ml of 2% NOCC gel including SPER/NO(0.5mg/ml) was given. After 14 days, all animals were euthanatized, and a standard adhesion scoring system including extent and severity scores was applied by a blinded examiner. Results: The extent score in NOCC plus SPER/NO group was significantly lower than those of control and normal saline groups(p<0.05). The extent score in NOCC group was significantly lower than that of normal saline group(p<0.05). The extent score in NOCC plus SPER/NO group was significantly lower than that of SPER/NO group(p<0.05). The severity score was significantly lower in NOCC plus SPER/NO and NOCC groups than that of control group(p<0.05). The severity score was significantly lower in NOCC plus SPER/NO group than that of SPER/NO group(p<0.05). Conclusions: Postoperative administration of NOCC gel and SPER/NO alone and especially in combination to the site of peritoneal injury reduces the formation of adhesions in the rat uterine horn model. (author abst.) |
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