Possible Role of Genetic Factor(s) on Age-related Increase of Peripheral CD4+CD8+ Double Positive T Cells in Cynomolgus Monkeys.
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Accession number;03A0583408
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| Title;Possible Role of Genetic Factor(s) on Age-related Increase of Peripheral CD4+CD8+ Double Positive T Cells in Cynomolgus Monkeys. |
| Author;
LEE W-W
(National Inst. Infectious Diseases, Ibaraki)
NAM K-H
(National Inst. Infectious Diseases, Ibaraki)
TERAO K
(National Inst. Infectious Diseases, Ibaraki)
YOSHIKAWA Y
(Univ. Tokyo, Tokyo)
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Journal Title;Exp Anim
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Journal Code:Z0755A
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ISSN:1341-1357
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VOL.52;NO.4;PAGE.309-316(2003)
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| Figure&Table&Reference;FIG.4, REF.30 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Mature TCR .ALPHA..BETA. T cells in peripheral blood are generally classified into either CD4 single positive(sp) T cells or CD8sp T cells. Several studies demonstrated that considerable amounts of CD4+CD8+ double positive(DP) T cells exist in peripheral blood of human and several animals. In particular, we previously reported that peripheral DP T cells increase in an age-related manner in cynomolgus monkeys(Macaca fascicularis), but the finding that DP T cells in some aged monkeys were maintained at a low proportion(under 5%), suggests that the increase in peripheral DP T cells might be genetically controlled in cynomolgus monkeys. To test this hypothesis, 24 families were randomly selected and used in a formal genetic analysis of the proportion of DP T cells. Parents and offspring in selected families were classified into DP-High and DP-Low groups based on a 5% cutoff level of DP T cells. The cutoff value was set by analysis of the distribution of the proportion of DP T cells. Nine out of 13 offspring(69.2%) with DP-High*DP-High parents belonged to the DP-High group, whereas three out of nine offspring(33.3%) belonged to DP-High group in the case of DP-High*DP-Low mating pairs. No offspring(0%) of two offspring with DP-Low*DP-Low parents belonged to the DP-High group. In addition, heritability(h2: narrow sense) obtained from the regression coefficient of offspring on mid-parent values was 0.54.+-.0.19. Both findings suggest that increases in DP T cells in cynomolgus monkeys may be genetically controlled. (author abst.) |
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