Production of Age-Related DNA Strand Breakage in Brain Cells of Senescence-Accelerated Prone(SAMP1) Mouse.
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Accession number;03A0583415
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| Title;Production of Age-Related DNA Strand Breakage in Brain Cells of Senescence-Accelerated Prone(SAMP1) Mouse. |
| Author;
HAYASHI M
(Rakuno Gakuen Univ., Ebetsu, Jpn)
NISHIDA K
(Rakuno Gakuen Univ., Ebetsu, Jpn)
ENDOH D
(Rakuno Gakuen Univ., Ebetsu, Jpn)
OKUI T
(Hokkaido Inst. Public Health, Sapporo, Jpn)
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Journal Title;Exp Anim
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Journal Code:Z0755A
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ISSN:1341-1357
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VOL.52;NO.4;PAGE.353-357(2003)
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| Figure&Table&Reference;FIG.1, REF.28 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Amounts of DNA strand breaks were estimated by the proportion of cells without tails(PCWT) and the average lengths of tail momentum(ALTM) in comet images of tissue cells of senescence-accelerated prone(SAMP1) mouse and senescence-accelerated resistant(SAMR1) mouse. The PCWT and ALTM of brain cells from SAMR1 were unchanged from 4 to 15 months of age. In the case of SAMP1 brain cells, the PCWT decreased and the ALTM increased in an age-related manner from 8 to 15 months of age. In the cases of liver and kidney, the PCWT and the ALTM of both SAMP1 and SAMR1 cells showed constant values from 4 to 15 months of ages. (author abst.) |
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