Immunohistochemical Analysis of Protein Gene Product 9.5, a Ubiquitin Carboxyl-terminal Hydrolase, during Placental and Embryonic Development in the Mouse.
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Accession number;03A0583417
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| Title;Immunohistochemical Analysis of Protein Gene Product 9.5, a Ubiquitin Carboxyl-terminal Hydrolase, during Placental and Embryonic Development in the Mouse. |
| Author;
SEKIGUCHI S
(Nippon Veterinary And Animal Sci. Univ., Tokyo, Jpn)
YOSHIKAWA Y
(Univ. Tokyo, Tokyo, Jpn)
TANAKA S
(Univ. Tokyo, Tokyo, Jpn)
KWON J
(Univ. Tokyo, Tokyo, Jpn)
ISHII Y
(Univ. Tokyo, Tokyo, Jpn)
KYUWA S
(Univ. Tokyo, Tokyo, Jpn)
WADA K
(National Inst. Neurosci., Tokyo, Jpn)
NAKAMURA S
(Nippon Veterinary And Animal Sci. Univ., Tokyo, Jpn)
TAKAHASHI K
(Nippon Veterinary And Animal Sci. Univ., Tokyo, Jpn)
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Journal Title;Exp Anim
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Journal Code:Z0755A
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ISSN:1341-1357
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VOL.52;NO.4;PAGE.365-369(2003)
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| Figure&Table&Reference;FIG.1, TBL.2, REF.25 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Protein gene product 9.5(PGP9.5) is expressed at high level in the neural and neuroendocrine systems. We investigated the localization and degree of expression of PGP9.5 in the developing mouse placenta and embryo at 6.5, 10.5 and 14 days of gestation using an immunohistochemical technique. At 6.5 days of gestation PGP9.5 was detected at various levels in decidual and primary trophoblast giant cells in the placenta, and in embryonic ectodermal cells in the embryo. At 10.5 and 14 days of gestation PGP9.5 was expressed at moderate to strong levels in neurons in the embryo, but rarely in the placenta. These findings suggest that the protein may play a significant role in implantation and placental development, and differentiation of embryonic ectoderm. (author abst.) |
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