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Accession number;03A0864363
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| Title;Control of food intake |
| Author;
KISHI KYOICHI
(Univ. of Tokushima, Sch. of Med.)
ROKUTAN KAZUHITO
(Univ. of Tokushima, Sch. of Med.)
NIKAWA TAKESHI
(Univ. of Tokushima, Sch. of Med.)
KONDO SHIGETADA
(Univ. of Tokushima, Sch. of Med.)
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Journal Title;Shikoku Acta Medica
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Journal Code:G0586A
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ISSN:0037-3699
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VOL.59;NO.4/5;PAGE.190-194(2003)
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| Figure&Table&Reference;TBL.4, REF.6 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Human disorders of food intake and body weight control are very complicated and are difficult to treat. One cause is the disruption of physiology of controlling feeding behavior and the other is the psychological origin. Hunger center in the lateral hypothalamus initiates feeding and satiety center in the ventromedial hypothalamus stops eating. There are a number of amines, peptides, hormones and drugs which modify feeding behavior. Metabolites of macronutrients such as glucose, fatty acids and amino acids are the signals to the hypothalamus. The liver plays a key role in controlling appetite, sending signals to the brain via vagus nerve. Recently, there has been important progress in the molecular genetics of animal obesity and leptin was discovered in 1994. More recently orexin and ghrelin have been found. The mechanism of food intake and body weight regulation has been investigated throughly but the prboblem of obesity is not solved yet. (author abst.) |
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