Science of adipose tissue
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Accession number;03A0864366
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| Title;Science of adipose tissue |
| Author;
NAKAYA YUTAKA
(Univ. of Tokushima, Sch. of Med.)
MATSUSHIMA RIE
(Univ. of Tokushima, Sch. of Med.)
MORISHIMA MASAKI
(Univ. of Tokushima, Sch. of Med.)
HARADA NAGAKATSU
(Univ. of Tokushima, Sch. of Med.)
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Journal Title;Shikoku Acta Medica
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Journal Code:G0586A
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ISSN:0037-3699
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VOL.59;NO.4/5;PAGE.211-213(2003)
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| Figure&Table&Reference;FIG.3, REF.6 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Adipose tissue secretes a variety of bioactive molecules (adipocytokines) that directly contribute to the development of life-style related diseases, such as diabetes, hypertension, and cardiovascular diseases. TNF-.ALPHA. is a well-known inhibitor of insulin signaling and PAI (plasminogen activator inhibitor)-1 contributes to thrombus formation. Adiponectin has an action both insulin sensitivity and anti-atherogenic action. Interestingly, low plasma adiponectin concentrations were observed in patients with obesity, coronary artery disease (CAD), and type 2 diabetes. Adiponectin from the plasma adhered to the injured artery and suppressed the endothelial expression of adhesion molecules, the proliferation of vascular smooth muscle cells, and the transformation of macrophage to foam cells. These findings support that accumulation of fat produces not only insulin resistance but also atherosclrosis in obese subjects. (author abst.) |
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