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Accession number;03A0864368
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| Title;The Brugada syndrome and its treatment |
| Author;
SAITO KEN
(School of Health Sci., Univ. Tokushima, JPN)
NOMURA MASAHIRO
(Univ. of Tokushima, Sch. of Med.)
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Journal Title;Shikoku Acta Medica
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Journal Code:G0586A
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ISSN:0037-3699
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VOL.59;NO.4/5;PAGE.220-227(2003)
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| Figure&Table&Reference;FIG.1, TBL.4, REF.38 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In 1992, Brugada brothers reported 8 patients with aborted sudden death without organic heart disease and exhibiting a characteristic ECG pattern of right bundle branch block (RBBB) and ST-segment elevation in right precordial leads (V1-V3). The syndrome is a familial disease and most frequently diagnosed in middle-aged men of Asian origin. The arrhythmic events such as polymorphic ventricular tachycardia (VT) or ventricular fibrillation (VF) are frequently generated during sleep. The Brugada syndrome has been linked to mutations in SCN5A, the gene encording for the .ALPHA.-subunit of the sodium channel. Sodium channel blockers (class IA and IC) identify the risk of sudden death in patients with the syndrome. Implantation of ICD is the only effective treatment of the VF for Brugada syndrome. The Brugada-type ECG in annual health examinations for adult citizens is not a very rare condition in Japan. Although it is reported that the mortality of subjects with the Brugada-type ECG in a community-based population is low compared with the mortality seen in a hospital-based study, there is also a report of the example of death in asymptomatic cases and the further study about a prognosis of Brugada syndrome is required. (author abst.) |
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