Influence of Food Intake on Pharmacokinetics of CS-866 (Olmesartan Medoxomil), an Angiotensin II Receptor Antagonist
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Accession number;03A0865485
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| Title;Influence of Food Intake on Pharmacokinetics of CS-866 (Olmesartan Medoxomil), an Angiotensin II Receptor Antagonist |
| Author;
TANAKA TAKANORI
(Aiseikai Osakikurinikku)
URAE RYUJI
(Aiseikai Osakikurinikku)
HISAOKA MASAFUMI
(Sankyo Co., Ltd., JPN)
SHIGA HIROSHI
(Sankyo Co., Ltd., JPN)
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Journal Title;Journal of Clinical Therapeutics & Medicines
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Journal Code:Y0906A
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ISSN:0910-8211
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VOL.19;NO.11;PAGE.1283-1295(2003)
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| Figure&Table&Reference;FIG.3, TBL.9, REF.8 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;CS-866 (Olmesartan medoxomil) is an orally active angiotensin II receptor antagonist and an antihypertensive agent. It is converted to an active metabolite, RNH-6270, after oral administration. The influence of food intake on pharmacokinetics of CS-866 at a single oral dosage was investigated in this trial. Twenty mg of CS-866 was orally administrated to 10 healthy male volunteers under fasting condition or 30 minutes after high-fat or low-fat meal in a three-way crossover manner. AUC0-24 and Cmax of RNH-6270 were compared among the three conditions and 95 % confidence intervals of all the ratios (fed with low-fat meal vs. fasted, fed with high-fat meal vs. fasted and fed with high-fat meal vs. fed with low-fat meal) were within the range from 0.8 to 1.25. 95 % confidence intervals of the difference in tmax of all pairs were below 1 hour. Therefore, pharmacokinetics of CS-866 was considered not to be affected by food intake. Concerning safety, no clinically significant abnormalities were confirmed after any type of food intake. (author abst.) |
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