PSYCHOPHARMACOTHERAPY FOR TIC DISORDERS OR TOURETTE SYNDROME AND TRICHOTILLOMANIA
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Accession number;03A0867728
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| Title;PSYCHOPHARMACOTHERAPY FOR TIC DISORDERS OR TOURETTE SYNDROME AND TRICHOTILLOMANIA |
| Author;
KANO YUKIKO
(Kitasato Univ., Graduate School of Medical Sci., JPN)
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Journal Title;Japanese Journal of Child and Adolescent Psychiatry
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Journal Code:Z0387B
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ISSN:0289-0968
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VOL.44;NO.4;PAGE.354-363(2003)
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| Figure&Table&Reference;REF.36 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Psychopharmacotherapy for tic disorders, especially Tourette syndrome and trichotillomania are reviewed. Psychopharmacotherapy is indicated when tic severity is estimated to be high in terms of (1) the symptoms shown, (2) impairment caused by tics, and (3) comorbidities. Psychopharmacotherapy consists of administering (1) neuroleptics for tics, (2) clonidine for both tics and comorbidities, and (3) stimulants and antidepressants for comorbidities. Atypical neuroleptic risperidone is recognized as an effective therapeutic agent for tics, as are haloperidol and pimozide. Although the use of stimulants has been regarded as a contraindication, several studies have reported AD/HD amelioration without clear exacerbation of tics in patients who suffer both from mild or moderate tics and AD/HD. Serotonin reuptake inhibitors combined with a low dose of neuroleptics are likely to be effective for treating comorbid obsessive-compulsive disorder in patients with tics, as well as for treating trichotillomania with obsessivity and impulsivity. Further research on the relationship between the clinical characteristics of tics and trichotillomania and brain functioning, including neurotransmitter imbalance, is needed. (author abst.) |
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