NATURAL KILLER CELL ACTIVITY AMONG PATIENTS WITH ATOPIC DERMATITIS
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Accession number;03A0868648
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| Title;NATURAL KILLER CELL ACTIVITY AMONG PATIENTS WITH ATOPIC DERMATITIS |
| Author;
SAKAI REIKO
(School of Medicine, Yokohama City Univ., JPN)
AIHARA MICHIKO
(School of Medicine, Yokohama City Univ., JPN)
ISHIWA MAMIKO
(School of Medicine, Yokohama City Univ., JPN)
NEGISHI AKI
(School of Medicine, Yokohama City Univ., JPN)
MATSUKURA SETSUKO
(School of Medicine, Yokohama City Univ., JPN)
TAKAHASHI KAZUO
(School of Medicine, Yokohama City Univ., JPN)
KIMURA HIROKAZU
(School of Medicine, Yokohama City Univ., JPN)
KOSAKA KENJI
(School of Medicine, Yokohama City Univ., JPN)
IKEZAWA ZENRO
(School of Medicine, Yokohama City Univ., JPN)
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Journal Title;Japanese Journal of Allergology
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Journal Code:Z0644A
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ISSN:0021-4884
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VOL.52;NO.11;PAGE.1074-1080(2003)
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| Figure&Table&Reference;TBL.4, REF.26 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We examined natural killer (NK) activity in 128 patients with atopic dermatitis (AD) to investigate the relationships between NK activity and severity of dermatitis, duration of disease, and mental states. The results showed the following: 1) No relationship was shown between severity of dermatitis and NK activity, neither between NK activity nor eosinophilic counts nor serum IgE. 2) Patients with longer duration of AD lesions showed significantly lower NK activity (P=0.036). The significant relationship was recognized between severity of dermatitis and the duration of disease (P=0.014). 3) No relationships were recognized between NK activity and mental states evaluated using the Profile Of Mood States (POMS) questionnaire, as tension-anxiety, depression-dejection, anger-hostility, vigor, fatigue and confusion. From a psychoneuroimmunological viewpoint, chronic stress as having AD might influence the lower NK activity of patients with longer duration of AD. (author abst.) |
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