IMMUNOTHERAPY BY JAPANESE CEDARPOLLEN IN ATPIC DERMATITIS
|
Accession number;03A0868649
|
| Title;IMMUNOTHERAPY BY JAPANESE CEDARPOLLEN IN ATPIC DERMATITIS |
| Author;
JUJI FUMIKO
(Nihon Rinsho Arerugi Kenkyusho)
KOBAYASHI SHIGETOSHI
(Teikyo Univ., Sch. of Med.)
ITO SHIGERU
(Tokatsubyoin Shonika)
SUGAWARA NAOTO
(Mitsubishi Kagaku Bio-Clinical Lab., Inc., JPN)
KANO HIROTSUGU
(Univ. of Tokyo, Fac. of Med.)
YASUEDA HIROSHI
(National Sagamihara Hospital, JPN)
IWATA TSUTOMU
(Univ. of Tokyo, Fac. of Med.)
|
Journal Title;Japanese Journal of Allergology
|
Journal Code:Z0644A
|
ISSN:0021-4884
|
|
VOL.52;NO.11;PAGE.1081-1088(2003)
|
| Figure&Table&Reference;FIG.7, TBL.1, REF.21 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Atopic dermatitis positive to Japanese cedar pollen showed the recurrence or worsening of the symptoms during the pollen season. In 22 cases, 6 children (mean, 11.4 y) and 16 adults (29.5 y) who showed positive to Japanese cedar pollen by RAST, CAST analysis were done by Cry j 1 0.01-10 .MU.g/ml and they showed the significant higher simulation indices compared to controls (P<0.01). Randomized analysis of the hyposensitized patients (10 cases) and non-hyposensitized (12 cases) showed significant lower stimulation indices in hyposensitized patients (P<0.01). In six cases stimulation indices were compared after one year of hyposensitization therapy. Four cases to whom hyposensitization were newly introduced showed the significant decreases of stimulation indices: 19.83.+-.4.97 (mean.+-.SEM) to 6.84.+-.6.36 (65.0%) by Cry j 1 0.01 .MU.g/ml, 19.73.+-.5.65 to 6.85.+-.1.78 (65.3%) by 0.1, 17.88.+-.5.11 to 6.36.+-.1.53 (64.4%) by 1, and 20.03.+-.5.29 to 6.11.+-.1.39 (69.5%) by 10, and they showed the significant decreases (P<0.05). By anti-IgE it decreased significantly from 35.08.+-.3.42 to 7.00.+-.1.77 (79.7%) (P<0.01). In two cases who got hyposensitization therapy for 2 years and 1 1/2 years each, there were no significant decreases of stimulation indices. The symptoms improved significantly and there were little or no recurrence of the symptoms. Symptom scores (Rajka & Langeland) showed significant decreases. Thus, hyposensitization by cedar pollen in atopic dermatitis is a promising treatment. (author abst.) |
|
|
|
Related Articles;
|
|
|
