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Accession number;04A0001874
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| Title;Adrenergic receptor signaling and regulation. |
| Author;
KUROSE HITOSHI
(Kyushu Univ., School of Phamaceutical Sciences, JPN)
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Journal Title;Folia Pharmacologica Japonica
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Journal Code:G0740A
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ISSN:0015-5691
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VOL.122;NO.;PAGE.8P-10P(2003)
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| Figure&Table&Reference;FIG.1, TBL.1, REF.4 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;At the beginning, .BETA.-arrestin is believed to regulate desensitization of G protein-coupled receptors. However, it becomes apparent that .BETA.-arrestin is involved in not only regulation but also signal transduction by identification of many proteins interacting with .BETA.-arrestin. So far, the model of regulation and signaling of G protein-coupled receptor is built on .BETA.2-adrenergic receptor. However, this model does not apply to all G protein-coupled receptors. The differential regulation and signaling between .BETA.1- and .BETA.2-adrenergic receptors is presented. (author abst.) |
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