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Accession number;04A0001875
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| Title;Molecular pharmacology of sarpogrelate. |
| Author;
NAGATOMO TAKAFUMI
(Niigata Univ. Pharmacy and Applied Life Sci., JPN)
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Journal Title;Folia Pharmacologica Japonica
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Journal Code:G0740A
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ISSN:0015-5691
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VOL.122;NO.;PAGE.11P-13P(2003)
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| Figure&Table&Reference;TBL.1, REF.5 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Sarpogrelate, a 5-HT2A antagonist, is used clinically as a therapeutic agent for ischemic blood vessels. Thus, the present study was designed to evaluate the selectivity to 5-HT2 subtypes, to assess the pharmacological effect using porcine coronary arteries and to demonstrate the identification of the binding sites using molecular modeling. Sarpogrelate was higher selectivity to 5-HT2A than those of ketanserin, ritanserin or cyproheptadine and these results were supported by the computer modeling. (author abst.) |
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