Improvements in Gastric Emptying by Trimebutine Maleate and Effects of Famotidine Coadministration
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Accession number;04A0011788
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| Title;Improvements in Gastric Emptying by Trimebutine Maleate and Effects of Famotidine Coadministration |
| Author;
HASHIMOTO YOSHIMI
(Yamanouchi Pharmaceutical Co., Ltd., JPN)
KISHIMOTO HIDEYUKI
(Yamanouchi Pharmaceutical Co., Ltd., JPN)
HASEGAWA KAZUMASA
(Yamanouchi Pharmaceutical Co., Ltd., JPN)
MAKITA YUMI
(Mitsubishi Chemical Safety Inst. Ltd., JPN)
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Journal Title;Clinical Pharmacology and Therapy
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Journal Code:L1701A
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ISSN:0917-3994
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VOL.13;NO.6;PAGE.565-571(2003)
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| Figure&Table&Reference;FIG.4, TBL.2, REF.11 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Using the method reported by Yoshida et al., a model for gastric emptying retardation in rats was prepared, and the gastric emptying effects of trimebutine maleate, an enterokinetic modulator, were evaluated according to the method reported by Jacoby et al.Administrations of trimebutine maleate at 10 and 30 mg/kg p.o. significantly improved gastric emptying in the rat model. Moreover, using this rat model, the effects of coadministration of trimebutine maleate with famotidine, a histamine H2-receptor antagonist, on gastric emptying were examined, confirming that the coadministration did not affect the gastric emptying improving action of trimebutine maleate. (author abst.) |
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