The Anti-ulcer Action of Famotidine, and Effects of Coadministration of Trimebutine Maleate
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Accession number;04A0011789
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| Title;The Anti-ulcer Action of Famotidine, and Effects of Coadministration of Trimebutine Maleate |
| Author;
HASHIMOTO YOSHIMI
(Yamanouchi Pharmaceutical Co., Ltd., JPN)
KISHIMOTO HIDEYUKI
(Yamanouchi Pharmaceutical Co., Ltd., JPN)
HASEGAWA KAZUMASA
(Yamanouchi Pharmaceutical Co., Ltd., JPN)
YAMAZAKI NORIYUKI
(Shin'yaku Kaihatsu Kenkyusho)
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Journal Title;Clinical Pharmacology and Therapy
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Journal Code:L1701A
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ISSN:0917-3994
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VOL.13;NO.6;PAGE.573-581(2003)
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| Figure&Table&Reference;FIG.4, TBL.4, REF.8 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The anti-ulcer action of famotidine were examined using rat ulcer models induced by hydrochloric acid-aspirin or histamine, and the effects of coadministration of trimebutine maleate, an enterokinetic modulator, were investigated. The dose of famotidine in this study was set based on the results of a previous dose-finding study. A median dose of trimebutine maleate was set at ten-fold of the famotidine dose, which has been established as a clinical dose for non-prescription use, then lower or higher trimebutine maleate doses were set by dividing or multiplying the median dose by a common ratio 3, respectively. Significant differences in the ulcer area were observed between rats receiving famotidine alone and control rats receiving distilled water only, while no significant differences were observed between rats coadministered famotidine and trimebutine maleate and those receiving famotidine alone. Namely, it was confirmed that famotidine exhibited a significant anti-ulcer effect in the ulcer models induced by hydrochloric acid-aspirin or histamine in rats, while coadministration with trimebutine maleate did not affect the famotidine action. (author abst.) |
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