The Gastric Acid Secretion Suppressive Action of Famotidine, and Effects of Coadministration of Trimebutine Maleate
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Accession number;04A0011790
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| Title;The Gastric Acid Secretion Suppressive Action of Famotidine, and Effects of Coadministration of Trimebutine Maleate |
| Author;
HASHIMOTO YOSHIMI
(Yamanouchi Pharmaceutical Co., Ltd., JPN)
KISHIMOTO HIDEYUKI
(Yamanouchi Pharmaceutical Co., Ltd., JPN)
HASEGAWA KAZUMASA
(Yamanouchi Pharmaceutical Co., Ltd., JPN)
YAMAZAKI NORIYUKI
(Shin'yaku Kaihatsu Kenkyusho)
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Journal Title;Clinical Pharmacology and Therapy
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Journal Code:L1701A
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ISSN:0917-3994
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VOL.13;NO.6;PAGE.583-589(2003)
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| Figure&Table&Reference;FIG.3, TBL.4, REF.7 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The gastric acid secretion suppressive action of famotidine using a histamine-induced gastric hyperacidity rat model, and the effects of coadministration of trimebutine maleate, an enterokinetic modulator, were investigated. The dose of famotidine in this study was set at 1 mg/kg based on the results of a previous dose-finding study. A median dose of trimebutine maleate was set at ten-fold of the famotidine dose, which has been established as a clinical dose for non-prescription use, then lower or higher trimebutine maleate doses were set by dividing or multiplying the median dose by a common ratio 3, respectively. Control rats receiving distilled water exhibited gastric acid secretion of 9.5 mL, while it was 5.3 mL in rats receiving 1 mg/kg famotidine, a significant difference being observed. In contrast, coadministrations of trimebutine maleate at 3, 10, and 30 mg/kg with 1 mg/kg famotidine resulted in gastric acid secretions of 5.6, 5.6 and 4.9 mL, respectively, comparable to those observed in rats receiving famotidine alone. In addition, no effect of coadministration was noted in the pH value and total acidity of gastric secretion, which were evaluated as reference variables. Namely, famotidine was confirmed to be significantly effective in suppressing gastric acid secretion in the histamine-induced hyperacidity model in rats, while coadministration with trimebutine maleate did not affect the famotidine action. (author abst.) |
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