Effects of Famotidine and Trimebutine Maleate Alone or in a Combination on Liver Drug-metabolizing Enzymes in Rats
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Accession number;04A0011791
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| Title;Effects of Famotidine and Trimebutine Maleate Alone or in a Combination on Liver Drug-metabolizing Enzymes in Rats |
| Author;
HASHIMOTO YOSHIMI
(Yamanouchi Pharmaceutical Co., Ltd., JPN)
KISHIMOTO HIDEYUKI
(Yamanouchi Pharmaceutical Co., Ltd., JPN)
HASEGAWA KAZUMASA
(Yamanouchi Pharmaceutical Co., Ltd., JPN)
IWATA HIROSHI
(Mitsubishi Chemical Safety Inst. Ltd., JPN)
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Journal Title;Clinical Pharmacology and Therapy
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Journal Code:L1701A
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ISSN:0917-3994
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VOL.13;NO.6;PAGE.591-600(2003)
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| Figure&Table&Reference;TBL.5, REF.14 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Imasaki et al. reported that famotidine had no effects on liver drug-metabolizing enzymes in rats at doses of at least up to 100 mg/kg. Although famotidine is frequently used in combination with various drugs in clinical practice, the effects of the concomitant medications on liver drug-metabolizing enzymes have not been investigated. This study examined the effects of famotidine and trimebutine maleate, an enterokinetic modulator, alone or in combination on liver drug-metabolizing enzymes in rats. No significant changes in each enzymatic parameter were observed in any group of rats, suggesting that famotidine and trimebutine maleate alone or in combination have no effects on liver drug-metabolizing enzymes. (author abst.) |
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