5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone: A Pancreatic Lipase Inhibitor Isolated from Alpinia officinarum
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Accession number;04A0042370
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| Title;5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone: A Pancreatic Lipase Inhibitor Isolated from Alpinia officinarum |
| Author;
SHIN J-E
(Kyung Hee Univ., Seoul, Kor)
HAN M J
(Kyung Hee Univ., Seoul, Kor)
SONG M-C
(Kyung Hee Univ., Kyunggi-do, Kor)
BAEK N-I
(Kyung Hee Univ., Kyunggi-do, Kor)
KIM D-H
(Kyung Hee Univ., Seoul, Kor)
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Journal Title;Biol Pharm Bull
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Journal Code:S0989A
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ISSN:0918-6158
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VOL.27;NO.1;PAGE.138-140(2004)
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| Figure&Table&Reference;TBL.3, REF.12 |
| Pub. Country;Japan |
| Language;English |
| Abstract;A pancreatic lipase inhibitor, 5-hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (HPH), from the rhizome of Alpinia officinarum (AO) was isolated and its antihyperlipidemic activity was measured. HPH inhibited a pancreatic lipase with an IC50 value of 1.5 mg/ml (triolein as a substrate). HPH significantly lowered the serum TG level in corn oil feeding-induced triglyceridemic mice, and reduced serum triglyceride (TG) and cholesterol in Triton WR-1339-induced hyperlipidemic mice. However, HPH did not show hypolipidemic activity in high cholesterol diet-induced hyperlipidemic mice. Based on these findings, we propose that PL inhibitors may be effective as hypolipidemic agents. (author abst.) |
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