Trypanocidal Constituents in Plants 3. Leaves of Garcinia intermedia and Heartwood of Calophyllum brasiliense
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Accession number;04A0042371
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| Title;Trypanocidal Constituents in Plants 3. Leaves of Garcinia intermedia and Heartwood of Calophyllum brasiliense |
| Author;
ABE F
(Fukuoka Univ.)
NAGAFUJI S
(Fukuoka Univ.)
OKABE H
(Fukuoka Univ.)
AKAHANE H
(Fukuoka Univ. School Of Medicine, Fukuoka, Jpn)
ESTRADA-MUNIZ E
(National Univ. Mexico, Mexico, Mex)
HUERTA-REYES M
(National Univ. Mexico, Mexico, Mex)
REYES-CHILPA R
(National Univ. Mexico, Mexico, Mex)
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Journal Title;Biol Pharm Bull
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Journal Code:S0989A
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ISSN:0918-6158
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VOL.27;NO.1;PAGE.141-143(2004)
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| Figure&Table&Reference;TBL.1, REF.19 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The constituents of the leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense were investigated based on their trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent of Chagas' disease. As the active components, the polyisoprenylated benzophenone derivative guttiferone A and the xanthone 8-desoxygartanin were isolated along with the biflavonoids podocarpusflavone A and amentoflavone, and friedelin from the former. Three xanthones, jacareubin, 6-deoxyjacareubin, and 1,3,5,6-tetrahydroxy-2-(3-methyl-2-butenyl)xanthone from the latter showed activity. The trypanocidal activity of these compounds against trypomastigotes, an infectious form of T. cruzi, was examined as well as gossypol, berberine chloride, and harmine for comparison. (author abst.) |
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