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Accession number;04A0054980
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| Title;RAYNAUD-LIKE PHENOMENON IN INFANTS WITH ATOPIC DERMATITIS: Correlation with Serum Endothelin-1 Levels |
| Author;
KOJIMA TAKATSUGU
(Kojimaiin)
TANIUCHI SHOICHIRO
(Kansai Med. Univ.)
AOKI TAKAO
(Aokishonika)
HATANO YASUKO
(Kansai Med. Univ.)
YAMAMOTO AKEMI
(Kansai Med. Univ.)
SASAI MISA
(Kansai Med. Univ.)
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Journal Title;Japanese Journal of Allergology
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Journal Code:Z0644A
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ISSN:0021-4884
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VOL.52;NO.12;PAGE.1114-1121(2003)
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| Figure&Table&Reference;FIG.7, TBL.3, REF.25 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Infants with severe atopic dermatitis (AD) sometimes have cold and pale fingers and toes as observed in patients with Raynaud-like phenomenon (RP). We tried to clarify the physiological mechanism of secondary RP in patients with AD. The correlation between serum endothelin-1 (ET-1) or nitrate (NO3) levels and the severity of AD was examined in 37 patients. As a result, RP was observed in 5 boys younger than 6 months of age and with severe AD. These 5 infants had high serum ET-1 levels. However, serum NO3 levels were only mildly elevated. These results suggest that secondary RP in AD may occur with elevated ET-1 caused by stressed and/or damaged endothelium in infants with severe AD. (author abst.) |
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