Basic and Clinical Application Study of a Novel Anti-tumor Protein, PSP, Purified from Pig Liver
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Accession number;04A0022333
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| Title;Basic and Clinical Application Study of a Novel Anti-tumor Protein, PSP, Purified from Pig Liver |
| Author;
OKA TATSUZO
(Kagoshima Univ., Fac. Agriculture, JPN)
SUZUKI KEIKO
(Kagoshima Univ., Fac. Agriculture, JPN)
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Journal Title;Shokuniku ni kansuru Josei Kenkyu Chosa Seika Hokokusho
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Journal Code:X0296A
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ISSN:
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VOL.21;NO.;PAGE.108-111(2003)
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| Figure&Table&Reference;FIG.5, TBL.1, REF.6 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Perchloric acid-soluble protein(PSP) is a member of a new hypothetical family(YER057c/YJGF) of small proteins with presently unknown function. The high degree of evolutionary conservation of these proteins reflect an involvement in basic cellular regulation. The expression of PSP was examined in rat hepatoma cell dRLh 84-beared rats. The tumor weight increased to 4.24g at 3 weeks after the transplantation of hepatoma cell and hepatoma which has less differentiated characteristics were observed in rat liver. The expression of PSP in rat hepatoma was down regulated as compared with intact tissue. Thus the expression of PSP seems to be associated with the differentiation process in these transformed cells. On the other hand, some positive cells against the PSP-antibody were observed in the central region of tumor tissue by immunohistochmistry. These cells were shown to be the lymphocytes and the macrophages. (author abst.) |
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