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Accession number;04A0022337
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| Title;Effect of Supplemental Propionate on Blood Glucose Metabolism and Insulin Action in Sheep |
| Author;
SANO HIROAKI
(Iwate Univ., Faculty of Agriculture, JPN)
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Journal Title;Shokuniku ni kansuru Josei Kenkyu Chosa Seika Hokokusho
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Journal Code:X0296A
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ISSN:
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VOL.21;NO.;PAGE.128-132(2003)
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| Figure&Table&Reference;TBL.1, REF.8 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Combined experiments of an isotope dilution method of [U-13C]gluocse and a glucose clamp procedure were applied to determine the effect of supplemental calcium propionate on blood glucose metabolism and insulin action in four sheep. Basal diets consisted of alfalfa hay cubes and commercial concentrates. They were fed the basal diet only(Control treatment) and the basal diet with calcium propioante supplementation(10mmol/kg/day; Propionate diet). The experiment was conduceted with the cross-over design for each 3-week period. [U-13C]Glucose was infused at rates of 120.MU.g/min for 12h after a priming injection. For the latter 8-h period of the isotope dilution method, insulin was infused over four sequential 2-h periods at rates of 0.64, 1.6, 4.0 and 10mU/kg/min and a 20% glucose solution was variably infused to maintain euglycemia. Blood concentrations and plasma isotope enrichments of glucose were determined and blood glucose turnover rate was calculated. Blood glucose turnover rate at preinfusion was higher for the Propionate treatment than for the Control treatment. Blood glucose turnover rate increased with insulin infusion rate increased in both dietary treatments. The increase in blood glucose turnover rate and the ratio of endogenous glucose production rate to blood glucose turnover rate were greater for the Propionate treatment than for the Control treatment. These results suggest that in sheep blood glucose metabolism and insulin action to glucose metabolism enhance with propionate supplementation. (author abst.) |
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