Science Links Japan | Skeletal Muscle Satellite Cells as Mesenchymal Multipotent Stem Cells: Studies on the mechanism underlying their adipogenic differentiation

Skeletal Muscle Satellite Cells as Mesenchymal Multipotent Stem Cells: Studies on the mechanism underlying their adipogenic differentiation

Accession number;04A0022340

Title;Skeletal Muscle Satellite Cells as Mesenchymal Multipotent Stem Cells: Studies on the mechanism underlying their adipogenic differentiation

Author; YAMANOUCHI KEITARO (Univ. Tokyo, Graduate School of Agricaltural and Life Sci., JPN) YADA ERIKA (Univ. Tokyo, Graduate School of Agricaltural and Life Sci., JPN) NISHIHARA MASUGI (Univ. Tokyo, Graduate School of Agricaltural and Life Sci., JPN)

Journal Title;Shokuniku ni kansuru Josei Kenkyu Chosa Seika Hokokusho

Journal Code:X0296A

ISSN:

VOL.21;NO.;PAGE.143-149(2003)

Figure&Table&Reference;FIG.3, REF.12

Pub. Country;Japan

Language;Japanese

Abstract;Skeletal muscle satellite cells are categorized into so-called tissue specific stem cells due to their ability to participate in regeneration/growth of skeletal muscle. Recent evidences indicate that they are also capable of differentiating to other cell lineages such as adipocytes, chondrocytes and osteocytes. Skeletal muscles are known to accumulate adipocytes under some circumstance such as aging, muscular dystrophy and denervation but the exact origin of these accumulated adipocytes within this tissue is still unknown. Looking on their multipotency, we hypothesized that satellite cells might be differentiating to adipogenic lineage within skeletal muscle under some specific environment, and that this would be resulting in the accumulation of adipocytes within this tissue. Therefore, the present study was conducted to test this hypothesis and clarify the mechanism underlying adipogenic differentiation of satellite cells in vivo. Rat satellite cells from soleus muscle showed higher adipogenesity than the cells from tibialis anterior muscle, suggesting that their potencies are different between the cells from slow twich- and fast twich-muscles. In addition, satellite cells from old animals were highly capable of differentiating to adipocytes compared to the cells from young animals. Based on these findings, the studies to clarify the states of skeletal muscle fibres and endocrine environments that could affect on the adipogenic behavior of satellite cells are currently ongoing. (author abst.)

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