Acute necrotizing pancreatitis in a case of Vogt-Koyanagi-Harada disease during sytemic corticosteroid treatment.

Accession number;04A0049661
Title;Acute necrotizing pancreatitis in a case of Vogt-Koyanagi-Harada disease during sytemic corticosteroid treatment.
Author; NAGAYAMA AKIKO (Hamamatsu Medical Center, JPN) () IWAOKA YASUSHI (Kenseibuhamamatsuiryose Shokakinaika) KUSANO TOSHIOMI (Hamamatsu Medical Center, JPN)
Journal Title;Japanese Journal of Clinical Ophthalmology
Journal Code:Z0515B
ISSN:0370-5579
VOL.58;NO.1;PAGE.81-85(2004)
Figure&Table&Reference;FIG.5, REF.12
Pub. Country;Japan
Language;Japanese
Abstract;A 56-year-old woman was referred to us for headache and blurring of vision since 3 days before. Her corrected visual acuity was 0.6 right and 0.5 left. Both eyes showed iritis and serous retinal detachment. Fluorescein angiography showed subretinal dye pooling. We diagnosed her with Vogt-Koyanagi-Harada disease and started intravenous infusion of betamethasone. The initial daily dosis of 8mg was increased to 10mg from the third day on. When the accumulated dosis reached 84mg 10 days after start of treatment, she developed abdominal pain and signs of acute peritonitis. During laparatomy performed 2 days later, the pancreas was found to have resolved and necrotized. Partial pancreatectomy and splenectomy were performed. She recovered full visual acuity after developing sunset-glow fundus. This case illustrates that acute necrotizing pancreatitis is a liability following systemic corticosteroid treatment. (author abst.)