Combined Effects of Hyaluronan and Artificial Tear Solution in Rat Dry Eye Model
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Accession number;04A0090428
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| Title;Combined Effects of Hyaluronan and Artificial Tear Solution in Rat Dry Eye Model |
| Author;
MURAKAMI TADAHIRO
(Santen Pharmaceutical Co,. Ltd., JPN)
NAKAMURA MASATSUGU
(Santen Pharmaceutical Co,. Ltd., JPN)
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Journal Title;Journal of the Eye
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Journal Code:Y0754A
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ISSN:0910-1810
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VOL.21;NO.1;PAGE.87-90(2004)
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| Figure&Table&Reference;FIG.3, REF.13 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We examined the combined effects of hyaluronan and artificial tear solution on fluorescein staining score following exorbital lacrimal gland removal in the rat dry eye model. The application of artificial tear solution, hyaluronan, or a combination of both was initiated 8 weeks after extirpation of the exorbital lacrimal glands. These eyedrops were applied 6 times daily for 3 weeks, and fluorescein staining was scored before and at 1, 2 and 3 weeks of application. The application of hyaluronan and the combination of hyaluronan with artificial tear solution significantly decreased the fluorescein staining score compared with the artificial tear solution during the experimental period. Furthermore, the combination of hyaluronan with artificial tear solution tended to be more effective than hyaluronan alone. These results suggest that in the rat dry eye model, hyaluronan improves corneal epithehal damage, and that the combination of hyaluronan with artificial tear solution may be more effective than hyaluronan alone. (author abst.) |
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