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Accession number;04A0108800
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| Title;Comparative Pharmacokinetic Behavior of Glycyrrhetic Acid after Oral Administration of Glycyrrhizic Acid and Gancao-Fuzi-Tang |
| Author;
GAO Q-T
(Shenyang Pharmaceutical Univ., Shenyang, Chn)
CHEN X-H
(Shenyang Pharmaceutical Univ., Shenyang, Chn)
BI K-S
(Shenyang Pharmaceutical Univ., Shenyang, Chn)
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Journal Title;Biol Pharm Bull
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Journal Code:S0989A
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ISSN:0918-6158
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VOL.27;NO.2;PAGE.226-228(2004)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.22 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Comparative pharmacokinetic profiles of glycyrrhetic acid (GA), glycyrrhizic acid (GL) and Gancao-Fuzi-Tang (KF) after oral administration of GL and KF were studied. Plasma samples taken from rats were acidified with acetic acid and GA was extracted with isopropanol-ethyl ether (1 : 1). Separation of GA was performed on a C18 column with the detection wavelength set at 254 nm. The mobile phase was methanol-acetonitrile-water-acetic acid (58 : 18 : 24 : 1 v/v). The results showed that the mean residence time and area under the curve of GA in KF-administered rats were 27.6.+-.1.5 h and 122.8.+-.46.7 .MU.g h/ml respectively, which were significantly different from those in GL-administered rats (15.0.+-.2.0 h and 40.9.+-.9.6 .MU.g h/ml, respectively). The results suggest the increased effect of GA after oral administration of KF in comparison with GL. (author abst.) |
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