Evaluation of Clinical Outcome of Long-Term Intravesical Oxybutynin Therapy-Hospital Pharmaceutical Preparations Improved QOL for Patients with Refractory Urinary Incontinence-
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Accession number;04A0143387
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| Title;Evaluation of Clinical Outcome of Long-Term Intravesical Oxybutynin Therapy-Hospital Pharmaceutical Preparations Improved QOL for Patients with Refractory Urinary Incontinence- |
| Author;
YAMASHITA YASUNORI
(Asahikawa Medical Coll., Hospital, JPN)
CHIBA KAORU
(Asahikawa Medical Coll., Hospital, JPN)
ONO TAKASHI
(Asahikawa Medical Coll., Hospital, JPN)
KOEDA MASAYOSHI
(Asahikawa Medical Coll., Hospital, JPN)
SUNO MANABU
(Asahikawa Medical Coll., Hospital, JPN)
OGAWA SATOSHI
(Asahikawa Medical Coll., Hospital, JPN)
KASAHARA NAOKUNI
(Asahikawa Medical Coll., Hospital, JPN)
TANIGUCHI NARUMI
(Asahikawa Medical Coll., Hospital, JPN)
MIZUNAGA MITSUHIRO
(Jin'yukai Hinyokakinaikakurinikku)
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Journal Title;Japanese Journal of Pharmaceutical Health Care and Sciences
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Journal Code:Y0888A
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ISSN:1346-342X
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VOL.30;NO.2;PAGE.83-87(2004)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.21 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The clinical outcome of long-term intravesical oxybutynin therapy to treat refractory urinary incontinence in 19 patients with a neuropathic bladder was evaluated by means of a questionnaire survey. Therapy consisted of self-instillation of a 10 mL solution containing 5 mg oxybutynin hydrochloride, which was prepared under sterile conditions in our hospital pharmacy, once (5 patients) or twice (14 patients) a day. Seventeen out of the 19 patients responded to the questionnaire and their mean therapy period was 7.3 years (2.5-10.3 years). Among them, only one became completely free of urinary incontinence. The patient response rate for effective or better regarding the efficacy of the drug was 76.5% indicating that a large number of them were satisfied with the treatment. No patient experienced any serious local or systemic adverse effects. These results show that the quality of life of the patients was improved by long-term intravesical oxybutynin therapy. They also suggest that intravesical oxybutynin would be an effective and safe therapy for patients with a neuropathic bladder, who do not respond to oral medication or suffer from intolerable adverse effects due to it. (author abst.) |
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