Science Links Japan | SURGICAL MANAGEMENT AND PROGNOSTIC FACTOR IN PATIENTS WITH ADVANCED ORAL CARCINOMA-APPLICATION FOR CONSERVATIVE SURGERY ACCORDING TO MODE OF INVASION AND EFFECTS OF PREOPERATIVE TREATMENT-

SURGICAL MANAGEMENT AND PROGNOSTIC FACTOR IN PATIENTS WITH ADVANCED ORAL CARCINOMA-APPLICATION FOR CONSERVATIVE SURGERY ACCORDING TO MODE OF INVASION AND EFFECTS OF PREOPERATIVE TREATMENT-

Accession number;04A0146737

Title;SURGICAL MANAGEMENT AND PROGNOSTIC FACTOR IN PATIENTS WITH ADVANCED ORAL CARCINOMA-APPLICATION FOR CONSERVATIVE SURGERY ACCORDING TO MODE OF INVASION AND EFFECTS OF PREOPERATIVE TREATMENT-

Author; KINJO HISANORI (School of Medicine, Sapporo Medical Univ., JPN) NOGUCHI MAKOTO (School of Medicine, Sapporo Medical Univ., JPN) KIDO YUKIE (School of Medicine, Sapporo Medical Univ., JPN) MIYAZAKI AKIHIRO (School of Medicine, Sapporo Medical Univ., JPN) KUBOTA HIROMI (School of Medicine, Sapporo Medical Univ., JPN) TAKEMURA KANAKO (School of Medicine, Sapporo Medical Univ., JPN) KOHAMA GEN'IKU (School of Medicine, Sapporo Medical Univ., JPN)

Journal Title;Head and Neck Cancer

Journal Code:Y0503A

ISSN:0911-4335

VOL.28;NO.1;PAGE.62-67(2002)

Figure&Table&Reference;FIG.1, TBL.3, REF.15

Pub. Country;Japan

Language;Japanese

Abstract;To elucidate application for conservative surgery in advanced oral carcinoma (Stage III, IV), this study retrospectively analyzed our treatment results and prognostic factors in 194 patients with previously untreated advanced oral carcinoma who were surgically managed between 1976 and 2000. The primary site distribution was as follows: 75 tumors located in the tongue; 33 tumors in the floor of the mouth; 54 tumors in the lower gum; 10 tumors in the upper gum; 21 tumors in the buccal mucosa; and 1 tumor in the lower lip. Eighty-four patients were in stage III and 110 were in stage IV. Seven, 55, 48, 84 patients had T1, T2, T3 and T4 respectively. The 5-year cumulative disease-specific survival rate (5-year SR) for all 194 patients was 63.9%, consisting of 80.2% for stage III and 52.1% for stage IV. The 5 year SR according to mode of invasion (1-3, 4C+4D) and effects of preoperative treatment (response, no response) were as follows: mode 1-3+response, 76.9%; mode 1-3+non response, 74.3%; mode 4C, 4D+response, 64.7%; mode 4C, 4D+no response, 31.0%. In univariate analysis, 6 parameters (T stage, N stage, clinical stage, growth pattern, histopathological grading and mode of invasion) had significant impact on disease-specific survival. When the data were analyzed by Cox's multivariate regression, three factors significantly affected survival and these were T stage (1-3, 4), N stage (0, 1-3) and mode of invasion (1+2, 3, 4C+4D). The findings of the present study suggest that patients with low-moderate malignancy grade and good response to preoperative treatment could undergo surgical treatment without oral disorder. (author abst.)

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