EVALUATION OF CERVICAL METASTASES OF UNKNOWN PRIMARY SITE
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Accession number;04A0146747
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| Title;EVALUATION OF CERVICAL METASTASES OF UNKNOWN PRIMARY SITE |
| Author;
KOMATSUZAKI YASUSHI
(St. Marianna Univ. School of Medicine, Toyoko Hospital, JPN)
SUGIURA NATSUKI
(St. Marianna Univ. School of Medicine, Toyoko Hospital, JPN)
OCHI KENTARO
(St. Marianna Univ. School of Medicine, Toyoko Hospital, JPN)
IWATAKE HIROYA
(St. Marianna Univ. School of Medicine, JPN)
TSUTSUMI KOICHIRO
(St. Marianna Univ. School of Medicine, JPN)
KOIZUKA IZUMI
(St. Marianna Univ. School of Medicine, JPN)
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Journal Title;Head and Neck Cancer
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Journal Code:Y0503A
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ISSN:0911-4335
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VOL.28;NO.1;PAGE.119-124(2002)
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| Figure&Table&Reference;FIG.2, TBL.2, REF.9 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Clinical courses of 11 patients with metastatic cervical tumor from unknown primary sites were retrospectively analyzed. Histopathological examination of these tumors revealed squamous cell carcinoma in all cases. Neck dissection was performed as an initial treatment in 10 of 11 patients. Eight of these ten patients underwent chemotherapy after operation, one patient was treated with surgery alone and one patient underwent radiotherapy. The primary sites were identified after initial treatment in five cases after operation (oropharynx, 3 cases; hypopharynx, 1 case; esophagus, 1 case). The mean duration between the determination of the primary site and initial treatment of these five cases was 22 months. Distant metastases occurred in two of five cases whose primary site was identified. The primary site was never identified in the other six patients. One patient who had inoperable cervical tumors and poor systemic status died without radical treatment. The other five patients underwent neck dissection as an initial treatment. The distant metastases occurred in four of five cases and local recurrence appeared in all cases after initial treatment. The prognosis of these cases was poor regardless of identification of the primary site after initial treatment. The five-year cumulative survival rate was 20.0% in patients whose primary site was not identified after initial treatment while 66.7% in patients whose primary site was identified. The difference between the former survival rate and the latter one was not statistically significant. Neck dissection may be of some benefit for these patients. As an initial treatment, further study is necessary to determine the effectiveness of adjuvant therapy such as chemotherapy and/or radiotherapy. (author abst.) |
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