PRELIMINARY RESULTS OF CARBON ION RADIOTHERAPY FOR ADENOCARCINOMAS OF THE HEAD AND NECK
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Accession number;04A0146759
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| Title;PRELIMINARY RESULTS OF CARBON ION RADIOTHERAPY FOR ADENOCARCINOMAS OF THE HEAD AND NECK |
| Author;
MIZOE JUN'ETSU
(National Inst. Radiological Sci., JPN)
TSUJII HIROHIKO
(National Inst. Radiological Sci., JPN)
KONNO MASAYOSHI
(Chiba Univ., School of Medicine, JPN)
EBIHARA SATOSHI
(National Cancer Center Hospital East, JPN)
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Journal Title;Head and Neck Cancer
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Journal Code:Y0503A
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ISSN:0911-4335
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VOL.28;NO.1;PAGE.192-197(2002)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.20 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Carbon ion radiotherapy for head and neck malignancies, which has been performed since April of 1997, was analyzed preliminarily. Of 101 head and neck patients who were treated till August 2000, 37 cases with adenocarcinomas were analyzed. They consisted of 13 cases of adenocarcinoma (AC), 16 cases of adenoid cystic carcinoma (ACC), and 8 cases with papillary adenocarcinoma (PAC) of the thyroid. There were 11 males and 2 females in AC, 6 males and 10 females in ACC, and 4 males and 4 females in PAC. Age ranged from 45 to 75 (average, 60 years old) in AC, from 39 to 79 (52) in ACC, and from 39 to 78 (69) in PAC. Target volume ranged from 31 to 484cc (average of 206cc) in AC, from 58 to 530cc (210cc) in ACC, and from 108 to 407 (253cc) in PAC. Thirty-five cases were treated with 57.6GyE/16 fractions/4 weeks, and 2 cases were treated with 64.0GyE/16 fractions/4 weeks. There was no acute reaction more than grade 3 (RTOG/EORTC) in normal tissues, and all of the patients completed their scheduled irradiations. The three-year local control rate (LCR) of AC was 91%, and the three-year survival rate (SR) was 74% by the Kaplan-Meier method. In ACC, the three-year LCR was 100% and the three-year SR was 54%. In PAC, the three-year LCR was 83%, and the three-year SR was 38%. There were 2 cases of lymph node metastases, and 3 cases with distant metastases, in AC. Also, there were 2 cases with lymph node metastases, 2 cases with meningeal spread, and 6 cases with distant metastases, in ACC. In PAC, there were 3 cases with lymph node metastases. These metastases were the main causes of death of the patients. (author abst.) |
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