PHASE II STUDY OF CONCURRENT CHEOMORADIOTHERAPY FOR LARYNGEAL PRESERVATION USING CISPLATIN ALONE
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Accession number;04A0146765
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| Title;PHASE II STUDY OF CONCURRENT CHEOMORADIOTHERAPY FOR LARYNGEAL PRESERVATION USING CISPLATIN ALONE |
| Author;
MYOJIN MIYAKO
(Sapporo National Hospital, JPN)
NISHIO MASAMICHI
(Sapporo National Hospital, JPN)
NISHIYAMA NORIAKI
(Sapporo National Hospital, JPN)
SHIRAI KEISUKE
(Sapporo National Hospital, JPN)
TANAKA KATSUHIKO
(Sapporo National Hospital, JPN)
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Journal Title;Head and Neck Cancer
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Journal Code:Y0503A
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ISSN:0911-4335
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VOL.28;NO.1;PAGE.231-236(2002)
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| Figure&Table&Reference;FIG.2, TBL.3, REF.12 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;To improve disease specific survival (DSS) and avoid laryngectomy in patients with Stage II to IV resectible cancer in the oropharynx, hypopharynx and supraglottis, forty-two cases registered in a phase II non-randomized prospective study on concurrent chemoradiotherapy using Cisplatin (CDDP) from May 1992 to June 1999. Median follow-up time was 42 months (6-118 months). Definitive radiation dose was 66Gy/30F/7.5 weeks, except for the cases evaluated for scheduled surgery at 40 to 45Gy. Two cycles of chemotherapy (20mg/m2 of CDDP, days 1, 2, 4, 5) were administered during the overall treatment time. T3-4 was 50% (2 T1, 19 T2, 14 T3, 7 T4), and Stage III & IV was 79% (1 Stage I, 8 Stage II, 13 Stage III, 20 Stage IV). Primary sites were oropharygeal anterior wall (8), oropharyngeal posterior wall (3), hypopharynx (19) and supraglottis (12). Five-year DSS was 81% and 5-year local control rate was 76% in all 42 cases. The complete response rate within 2 months after RT completion was 36/42 (86%) for the primary site and 18/24 (75%) for the neck. The laryngeal preserving rate was 63% at 5 years. These data were compared with those of the control cases treated with RT+Surgery, which has been selected from a historical database for the matched pair analysis. Five-year DSS and laryngeal preservation rate in the chemoradiation group were significantly better (p=0.0263 and p=0.0085) than those (51% and 40%) in the control group, respectively. Only one Grade 4 complication was shown as leucocytopenia and pneumonia but was recovered. It was concluded that concurrent chemoradiation using CDDP appears to result in distinct improvement of DSS and laryngeal preservation. (author abst.) |
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