USE OF cDNA MICROARRAY TO ANALYZE GENE EXPRESSION AFTER HYPERTHERMIA IN LOW pH CULTURE CONDITION
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Accession number;04A0146770
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| Title;USE OF cDNA MICROARRAY TO ANALYZE GENE EXPRESSION AFTER HYPERTHERMIA IN LOW pH CULTURE CONDITION |
| Author;
NARITA NORIHIKO
(Fac. Medicine, Fukui Medical Univ., JPN)
OTSUBO TOSHIO
(Fac. Medicine, Fukui Medical Univ., JPN)
NODA ICHIRO
(Fac. Medicine, Fukui Medical Univ., JPN)
IGAWA HIDEKI
(Fac. Medicine, Fukui Medical Univ., JPN)
TOKURIKI MASAHARU
(Fac. Medicine, Fukui Medical Univ., JPN)
SAITO TAKEHISA
(Fac. Medicine, Fukui Medical Univ., JPN)
SAITO HITOSHI
(Fac. Medicine, Fukui Medical Univ., JPN)
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Journal Title;Head and Neck Cancer
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Journal Code:Y0503A
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ISSN:0911-4335
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VOL.28;NO.1;PAGE.259-263(2002)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.13 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;cDNA microarray Was used to identify genes regulated in response to hyperthermia in a low pH culture condition using IMC-3 cells, a human maxillary cancer cell line. cDNA microarray and reverse transcription-PCR (RT-PCR) were performed. Eighteen genes were found to be up-regulated by hyperthermia at a low pH culture. These include genes involved in cell cycle checkpoint control, genes for signal transduction proteins as well as genes associated with apoptosis. The observed change in gene expression may play a role in enhancement of heatinduced cell death in a low pH culture condition. (author abst.) |
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