A novel anti-aging ingredient-conjugating a vitamin with an amino acid.
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Accession number;04A0147403
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| Title;A novel anti-aging ingredient-conjugating a vitamin with an amino acid. |
| Author;
ISHITSUKA YUKIKO
(Kose Corp., JPN)
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Journal Title;Fragr J
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Journal Code:G0987B
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ISSN:0288-9803
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VOL.32;NO.2;PAGE.44-48(2004)
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| Figure&Table&Reference;FIG.6, REF.12 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The reactive oxygen species produced by UV induces a harmful response in the skin, including lipid peroxidation, protein denaturation, DNA injury, and acute inflamation. It is considered that accumulation of these oxidative stresses is an important factor of skin aging, especially wrinkle formation. It is known that cutaneous iron catalyzes the production of hydroxyl radical via Fenton reaction and accelerates wrinkle formation. Several researchers have been investigating some iron chelators such as dipyridylamine, for the reduction of UV-induced oxidative stress. However, these materials are not useful for cosmetic ingredients. So, we synthesized the conjugate of pyridoxal (one form of vitamin B6) with serine, which is N-(4-pyridoxylmethylene)-L-serine (PYSer). We found that PYSer suppressed iron-induced hydroxyl radical generation and UVB-induced wrinkle formation and dermal hypertrophy in the hairless mice photoaging study. Here we introduced as a new material-PYSer with the novel function which is not in original vitamin B6. (author abst.) |
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