Pro-vitamin C of the second generation: L-ascorbyl-2-phosphate-6-palmitate trisodium salt. Its dermatological functions and application for cosmetics.
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Accession number;04A0147405
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| Title;Pro-vitamin C of the second generation: L-ascorbyl-2-phosphate-6-palmitate trisodium salt. Its dermatological functions and application for cosmetics. |
| Author;
KATO EIKO
(Showa Denko K.K., JPN)
TSUZUKI TOSHI
(Showa Denko K.K., JPN)
MIWA NOBUHIKO
(Hiroshima Prefectural Univ., School of Bioscience, JPN)
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Journal Title;Fragr J
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Journal Code:G0987B
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ISSN:0288-9803
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VOL.32;NO.2;PAGE.55-60(2004)
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| Figure&Table&Reference;FIG.8, REF.10 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The vitamin C derivative of the "Second Generation"-Physiological properties of a newly developed cosmetic ingredient, sodium L-ascorbyl 2-phosphate 6-palmitate (APPS) were evaluated. In a series of experiments using cultured cells and skin APPS exhibited a highly improved ascorbate (AsA) delivery to dermis compared to conventional AsA derivatives including sodium L-ascorbyl 2-phosphate (APS) and L-ascorbyl 2-glucoside (AG), quite supposedly thanks to its increased hydrophobicity. This AsA-enriching capability reflected on many cosmetological benefits; an outstanding enhancement of dermal collagen synthesis in vitro and in vivo, a quick quenching of UV-induced free radicals, and a inhibition of melanoma B16-derived tyrosinase system. Those findings suggest that APPS is suitable for the active ingredient of cosmetic products for anti-aging, anti-oxidative stress, and UV-care. (author abst.) |
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