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Accession number;04A0155703
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| Title;Hypotensive effect of unoprostone as adjunct to latanoprost during multiple drug therapy for glaucoma |
| Author;
KOBAYASHI HIROSHI
(Saga Univ., JPN)
IWAKIRI RYO
(Saga Univ., JPN)
KOBAYASHI KAORI
(Saga Univ., JPN)
OKINAMI SATOSHI
(Saga Univ., JPN)
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Journal Title;Japanese Journal of Clinical Ophthalmology
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Journal Code:Z0515B
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ISSN:0370-5579
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VOL.58;NO.2;PAGE.193-197(2004)
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| Figure&Table&Reference;FIG.1, TBL.4, REF.19 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose :To evaluate the hypotensive effect of 0.012% unoprostone when added to latanoprost in multiple drug treatment. Methods: Fifty eyes of 50 patients with primary open-angle glaucoma were enrolled in the study They had been receiving 0.5% timolol, 0.005% latanoprost and 1% dorzolamide for 3 months or longer. They were randomly divided into two groups of 25 eyes each. One group received unoprostone adjunctively. The other group continued the medication without unoprostone and served as control. Results: Baseline intraocular pressure (IOP) averaged 19.4.+-.2.5 mmHg in unoprostone group and 19.6.+-.2.4 mmHg in control group. There was no significant difference between the two values. Eight weeks after start of unoprostone, the IOP averaged 19.1.+-.1.9 mmHg in unoprostone group and 19.6.+-.2.4 mmHg in control group. There was no significant difference in IOP between both groups up to 8 weeks. In 17 eyes with baseline IOP of 22 mmHg or over, the IOP decreased 8 weeks later by 1.3.+-.1.0 mmHg in 8 eyes receiving unoprostone and by 0.1.+-.1.0 mmHg in 9 control eyes. The difference was significant (p=0.0324). There was no difference in IOP in 33 eyes with baseline IOP of 21 mmHg or less. Conclusion: Addition of unoprostone did not induce further ocular hypotension when seen as a whole. Only when the baseline IOP was 22 mmHg or over, additional unoprostone induced significant IOP reduction. (author abst.) |
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