Hypotensive effect and subjective symptoms after substitution of 1% dorzolamide by 1% brinzolamide
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Accession number;04A0155705
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| Title;Hypotensive effect and subjective symptoms after substitution of 1% dorzolamide by 1% brinzolamide |
| Author;
KOBAYASHI HIROSHI
(Saga Univ., JPN)
KOBAYASHI KAORI
(Saga Univ., JPN)
OKINAMI SATOSHI
(Saga Univ., JPN)
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Journal Title;Japanese Journal of Clinical Ophthalmology
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Journal Code:Z0515B
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ISSN:0370-5579
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VOL.58;NO.2;PAGE.205-209(2004)
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| Figure&Table&Reference;FIG.2, TBL.2, REF.11 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: To compare the hypotensive effect and comfort of 1% brinzolamide and 1% dorzolamide. Methods: A total of 60 eyes of 60 patients of primary open-angle glaucoma were enrolled in a prospective single-masked clinical study. They had been receiving 0.5% timolol, 0.005% latanoprost, and 1% dorzolamide for 3 months or longer. In 40 patients, dorzolamide was substituted by brinzolamide. The other 20 patients continued the regimen and served as control. No significant differences were present between the two groups regarding age, corrected visual acuity, mean deviation in Humphrey perimetry, or cupping/disc ratio. The baseline intraocular pressure (IOP) averaged 18.5.+-.3.4 mmHg in brinzolamide group and 18.9.+-.2.9 mmHg in control group. Results: There were no significant differences in IOP 4 and 8 weeks after substitution in either group. No differences were present between IOP levels in the two groups up to 8 weeks of observation. In brinzolamide group, 38 patients (95%) preferred brinzolamide 2. i. d. to dorzolamide 3. i. d. Conclusion: Same hypotensive effect was shown by 1% brinzolamide and 1% dorzolamide. Brinzolamide may improve compliance because of reduced frequency of instillation. (author abst.) |
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