Oxidative stress and cell damage in proliferative diabetic retinopathy
|
Accession number;04A0155706
|
| Title;Oxidative stress and cell damage in proliferative diabetic retinopathy |
| Author;
SATO HIROAKI
(Yamagata Univ., School of Medicine, JPN)
KAWASAKI RYO
(Yamagata Univ., School of Medicine, JPN)
YAMASHITA TETSUJI
(Mitsubishi Kagaku Bio-Clinical Lab., Inc., JPN)
TAKI SETSUKO
(Mitsubishi Kagaku Bio-Clinical Lab., Inc., JPN)
YAMASHITA HIDETOSHI
(Yamagata Univ., School of Medicine, JPN)
|
Journal Title;Japanese Journal of Clinical Ophthalmology
|
Journal Code:Z0515B
|
ISSN:0370-5579
|
|
VOL.58;NO.2;PAGE.211-216(2004)
|
| Figure&Table&Reference;FIG.6, TBL.1, REF.23 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Background: Oxidative stress may be involved in the etiology of proliferative diabetic retinopathy Purpose: To quantitate oxidative stress-related materials in human vitreous samples. Materials Vitreous aspirates were obtained in 46 eyes of 44 patients during vitreous surgery. The series comprised 24 males and 20 females. The ages averaged 61.6.+-.10.2 years. The causative lesions were proliferative diabetic retinopathy 18 eyes, vitreous hemorrhage secondary to branch retinal vein occlusion 7 eyes, and nonischemic vitreoretinopathy 21 eyes including macular hole 13 eyes, epimacular membrane 5 eyes and Terson syndrome 3 eyes. Panretinal photocoagulation had been performed in 16 eyes of diabetic retinopathy. Following four items were quantitated: vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and nitrous oxide (NO). Findings: Concentrations of all the four items were significantly higher in proliferative diabetic retinopathy than other diseases. The valur of IL-6 was significantly correlated with that of 8-OHdG (r=0.386, p=0.0081). Conclusion: The findings show that oxidative stress and cytokines are involved in proliferative diabetic retinopathy. (author abst.) |
|
|
|
Related Articles;
|
|
