Randomized Clinical Comparison of Healon V and Healon in Cataract and Intraocular Lens Surgery
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Accession number;04A0178221
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| Title;Randomized Clinical Comparison of Healon V and Healon in Cataract and Intraocular Lens Surgery |
| Author;
OSHIKA TETSURO
(Tsukubadai Rinshoigakukei Ganka)
MIYATA KAZUNORI
(Miyatagankabyoin)
SUGITA GENTARO
(Gankasugitabyoin)
OTA ICHIRO
(Gankamiyakebyoin)
BISSEN(MIYAJIMA) HIROKO
(Tokyo Dental Coll. School of Dentistry, Suidobashi Hospital, JPN)
YAGUCHI SHIGEO
(Showa Univ. Fujigaoka Hospital, JPN)
OKI KOTARO
(Okishika)
EGUCHI SHUICHIRO
(Eguchi Eye Hospital, JPN)
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Journal Title;Journal of the Eye
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Journal Code:Y0754A
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ISSN:0910-1810
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VOL.21;NO.2;PAGE.253-257(2004)
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| Figure&Table&Reference;FIG.7, TBL.1, REF.11 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Healon V and Healon were compared in terms of overall clinical performance during phacoemulsification and intraocular lens (IOL) implantation as well as their influence on intraocular pressure (IOP) and corneal endothelium. Subjects comprised 157 eyes of 157 patients who were randomly assigned to either Healon V (79 eyes) or Healon (78 eyes). Using a 5-point scale, surgeons evaluated the following: retention during phacoemulsification (primary endpoint), ease of injection, maintenance of anterior chamber during continuous curvilinear capsulorrhexis (CCC), facilitation of IOL implantation and ease of removal from the eye. Masked examiners other than the surgeon performed the following measurements: IOP presurgery and at 5 hours, 24 hours, 7 days, and 3 months postsurgery; corneal thickness presurgery and at 24 hours, 7 days, and 3 months postsurgery, and corneal endothelial cell count presurgery and at 3 months postsurgery. Intraocular retention during phacoemulsification was assessed as good or very good in 77% of the Healon V group compared to 8% of the Healon group, a statistically significant difference (p<0.0001, Wilcoxon rank-sum test). The Healon V group showed significantly better scores for retention during phacoemulsification (p<0.0001), maintenance of anterior chamber during CCC (p<0.0001), and facilitation of IOL implantation (p=0.032), whereas Healon was judged superior to Healon V in terms of ease of injection (p<0.0001) and ease of removal from the eye (p<0.0001). There were no statistically significant between group differences in IOP, corneal endothelial cell count, and corneal thickness. These findings indicate the efficacy and safety of Healon V in cataract surgery. (author abst.) |
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