One-Drop Effect of Brinzolamide on the Juxtapapillary Retinal Circulation in Normal Volunteers
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Accession number;04A0178225
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| Title;One-Drop Effect of Brinzolamide on the Juxtapapillary Retinal Circulation in Normal Volunteers |
| Author;
MAEDA SACHIE
(School of Medicine, Sapporo Medical Univ., JPN)
KONNO SHINSUKE
(School of Medicine, Sapporo Medical Univ., JPN)
OTSUKA KENJI
(School of Medicine, Sapporo Medical Univ., JPN)
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Journal Title;Journal of the Eye
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Journal Code:Y0754A
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ISSN:0910-1810
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VOL.21;NO.2;PAGE.271-274(2004)
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| Figure&Table&Reference;FIG.6, REF.16 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We studied the one-drop effect of brinzolamide on juxtapapillary retinal blood flow in 10 healthy normal volunteers, using a Heidelberg Retina Flowmeter (HRF). Eyes receiving brinzolamide comprised the brinzolamide group; fellow eyes reciving placebo comprised the placebo group. Changes in blood pressure, heart rate, intraocular pressure and retinal blood flow (volume, flow, velocity) were determined from measurements taken at baseline and at 1, 3, 6, 8 hours after instillation. Retinal blood flow did not increase significantly in either group from 1-8 hours after application. Intraocular pressure decreased significantly from 1-8 hours after application in the brinzolamide group, as compared with placebo group. The results suggest that one drop of brinzolamide does not increase juxtapapillary retinal circulation in normal eyes. (author abst.) |
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