Control of Arterial Pressure Variability Through Spinal Cord in Brain Damaged Rabbit
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Accession number;04A0208957
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| Title;Control of Arterial Pressure Variability Through Spinal Cord in Brain Damaged Rabbit |
| Author;
KAWAMOTO M
(Hiroshima Univ., Hiroshima, Jpn)
KURITA S
(Hiroshima Univ., Hiroshima, Jpn)
HIDAKA S
(Hiroshima Univ., Hiroshima, Jpn)
YUGE O
(Hiroshima Univ., Hiroshima, Jpn)
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Journal Title;Hiroshima Journal of Anesthesia
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Journal Code:S0305A
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ISSN:0385-1664
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VOL.39;NO.2;PAGE.57-64(2003)
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| Figure&Table&Reference;FIG.4, TBL.1, REF.19 |
| Pub. Country;Japan |
| Language;English |
| Abstract;To determine spinal cord function under a brain damaged condition, we measured heart rate (HR) variability (HRV) and systolic arterial pressure (SAP) variability, and analyzed impulse response analysis results between HR and SAP in brain damaged rabbits. Under general anesthesia, 16 male rabbits received artificial ventilation at 18 cycles/minute. They were divided into 2 groups, and received a spinal cord transection at C3-4 and brain damage by inflating an intracranial balloon. In the BS group, on-line data were digitally recorded prior to brain damage and for 60 minutes thereafter, after which the spinal cord was transected and data were recorded for an additional 60 minutes. In the SB group, the spinal cord was transected first and then the brain damage occurred, with the same recording intervals as in the BS group. HR and SAP variability were analyzed off-line. Spectral power was integrated at low (0.04-0.15Hz) and high (0.15-0.40Hz) frequency band areas. The impulse responses of HR to SAP and SAP to HR were analyzed by Fourier and inverse-Fourier transformations using data in the time domain. Statistical analysis was made within each group using a Scheffe test and variables at the same time points were compared between groups with an unpaired t test. Data are shown as mean .+-.SD, with p<0.05 determined to be statistically significant. Spinal transection significantly depressed HR, i.e., 187.+-.21 versus 221.+-.33bpm in SB and BS groups, respectively, and maintained a significant sympathovagal balance as shown by SAP variability (3.97.+-.1.24 vs. 1.68.+-.0.8), while brain damage significantly depressed the balance of HR variability (-0.03.+-.0.71 vs. 1.35.+-.1.48). As for the maximal impulse response of HR to SAP, brain damage had a greater effect than spinal cord damage, though no effect was seen in the impulse response of SAP to HR.... (author abst.) |
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