Supplemental Oxygen for the Prevention of Diaphragmatic Fatigability in Pentobarbital-Anesthetized Dogs
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Accession number;04A0208958
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| Title;Supplemental Oxygen for the Prevention of Diaphragmatic Fatigability in Pentobarbital-Anesthetized Dogs |
| Author;
UEMURA A
(Univ. Tsukuba, Ibaraki, Jpn)
FUJII Y
(Univ. Tsukuba Inst. Clinical Medicine, Ibaraki, Jpn)
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Journal Title;Hiroshima Journal of Anesthesia
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Journal Code:S0305A
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ISSN:0385-1664
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VOL.39;NO.2;PAGE.65-68(2003)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.12 |
| Pub. Country;Japan |
| Language;English |
| Abstract;We tested the hypothesis that supplemental oxygen administration prevents diaphragmatic fatigability in dogs. Pentobarbital-anesthetized animals were divided into 3 groups of 6 each. Group I received air (oxygen 21%); Group II received oxygen 50%, balance nitrogen; Group III received oxygen 80%, balance nitrogen. After maintaining 60min of stable condition, in each group, diaphragmatic fatigue was induced by intermittent supra-maximal bilateral electrophrenic stimulation at a frequency of 20-Hz applied for 30min. We assessed diaphragmatic contractility by transdiaphragmatic pressure (Pdi). After the fatigue-producing period, in each group, Pdi at low-frequency (20-Hz) stimulation decreased from baseline values (P<0.05), whereas there was no change in Pdi at high-frequency (100-Hz) stimulation. Compared with Group I, Pdi at 20-Hz stimulation in Group III showed higher values (P<0.05). There was no difference in values of Pdi at 20-Hz stimulation between Groups I and II. The integrated diaphragmatic electric activity (Edi) did not change in any group. We conclude that oxygen administration, when used at a higher concentration (80%), prevents diaphragmatic fatigability in pentobarbital-anesthetized dogs. (author abst.) |
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