Investigation of the Involvement of a Surfactant in the Leaching of Diethylhexyl Phthalate from Administration Sets
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Accession number;04A0212051
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| Title;Investigation of the Involvement of a Surfactant in the Leaching of Diethylhexyl Phthalate from Administration Sets |
| Author;
NAKAMURA YASUTAKA
(Chiba Univ., Univ. Hospital, JPN)
NAKAZAWA KAZUYOSHI
(Chiba Univ., Univ. Hospital, JPN)
OMORI SHIGERU
(Chiba Univ., Univ. Hospital, JPN)
KAWANO KENJI
(Niigata Univ. Pharmacy and Applied Life Sci., JPN)
NAKAJIMA SHIN'ICHIRO
(Yamanashi Medical Univ., Hospital, JPN)
KITADA MITSUKAZU
(Chiba Univ., Univ. Hospital, JPN)
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Journal Title;Japanese Journal of Pharmaceutical Health Care and Sciences
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Journal Code:Y0888A
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ISSN:1346-342X
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VOL.30;NO.3;PAGE.180-184(2004)
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| Figure&Table&Reference;FIG.6, REF.8 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Diethylhexyl phthalate (DEHP) is used in administration sets made of polyvinylchloride (PVC) as a plasticizer and such PVC administration sets are used frequently for intravenous drip infusions. However, it has been reported that the DEHP in administration tubes is dissolved by intravenous solutions containing solubilizing agents to aid continuous intravenous infusion. Since DEHP is suspected of being an endocrine disruptor, it should be prevented from entering the human body. With this in mind, we examined the DEHP leaching characteristics of a model solution containing the surfactant polyoxyethylated castor oil as the solubilizing agent. DEHP began to be leached from the administration set when the continuous infusion was started and the amount of DEHP leaching was found to increase in proportion to the concentration of the solubilizing agent, but decrease when the rate of flow was increased. The DEHP leaching pattern was similar when the model solution contained drugs. From these findings, we inferred that DEHP leaching is greatly influenced by the solubilizing agent. Though there have been no reports of DEHP having adverse effects, it should be prevented from entering the human body through the use of administration sets that do not contain it or changing the administration procedure. (author abst.) |
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