Effects of UV irradiation on the sebaceous gland and sebum in hamsters.
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Accession number;04A0230058
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| Title;Effects of UV irradiation on the sebaceous gland and sebum in hamsters. |
| Author;
AKITOMO YASUCHIYO
(Fac. Madicine, Kansai Medical Univ., JPN)
HORIO TAKESHI
(Fac. Madicine, Kansai Medical Univ., JPN)
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Journal Title;Fragr J
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Journal Code:G0987B
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ISSN:0288-9803
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VOL.32;NO.3;PAGE.19-25(2004)
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| Figure&Table&Reference;FIG.5, REF.31 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Although photobiology of the skin has extensively advanced recently, the effect of ultraviolet (UV) radiation on sebaceous glands is not well known. To know the direct effect of UV radiation on sebocytes, we used cultured sebocytes from hamsters. The number of sebocytes and the lipid production in sebocytes increased after UVB irradiation depending on the irradiated dose. When UVB was irradiated to the triglyceride (TG)- or cholesterol-applied skin at the minimum ear swelling dose, the transepidermal water loss (TEWL) increased. When in vitro-irradiated TG, in vitro-irradiated cholesterol, TG-peroxide and cholesterol-peroxide applied on the skin, the TEWL increased significantly. It was suggested that UV radiation in the sunlight could directly activate the function of sebaceous gland to secrete increased amounts of sebum on the skin surface. Further exposures to UV may peroxidate the skin surface lipids which damage the barrier functions of skin. This may explain the dry skin after exposure to UV light in summer, and dysfunction of the chronically UV-exposed skin. (author abst.) |
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