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Accession number;04A0241649
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| Title;Addition of topical bunazosin to latanoprost in multiple medical treatment for glaucoma |
| Author;
IWAKIRI RYO
(Saga Univ., JPN)
KOBAYASHI HIROSHI
(Saga Univ., JPN)
KOBAYASHI KAORI
(Saga Univ., JPN)
OKINAMI SATOSHI
(Saga Univ., JPN)
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Journal Title;Japanese Journal of Clinical Ophthalmology
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Journal Code:Z0515B
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ISSN:0370-5579
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VOL.58;NO.3;PAGE.359-362(2004)
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| Figure&Table&Reference;FIG.2, TBL.2, REF.19 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: To evaluate the ocular hypotensive effect of bunazosin hydrochloride 0.01 % added to multiple drug therapy including latanoprost 0.005%. Cases and Method: A total of 50 eyes of 50 patients with primary open-angle glaucoma were enrolled in the prospective study. They had been receiving timolol 0.5%, latanoprost 0.005% and dorzolamide 1% for at least 3 months. Randomly selected 25 eyes were additionally given bunazosin 0.01%, and the other 25 eyes served as control. They were followed up for 3 months. Findings: Baseline intraocular pressure (IOP) averaged 22.4.+-.1.8 mmHg in bunazosin group and 22.2.+-.2.0 mmHg in control group. IOP in bunazosin group decreased significantly by 1.4.+-.2.1 mmHg (p=0.0046) after 4 weeks and by 2.0.+-.1.7 mmHg (p=0.0008) after 12 weeks. IOP after 12 weeks also decreased significantly from IOP after 2 weeks (p=0.0344). IOP in the control group showed no significant differences from the baseline throughout. Conclusion: Additional bunazosin induced significant IOP reductions after 4 to 12 weeks. Since the hypotensive effect was small after 2 weeks, more than 4 weeks are necessary to evaluate the full effect of additional bunazosin. (author abst.) |
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