Effects of Sucralfate, Magnesium Oxide and Sodium Ferrous Citrate on Sparfloxacin Pharmacokinetics.
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Accession number;04A0078423
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| Title;Effects of Sucralfate, Magnesium Oxide and Sodium Ferrous Citrate on Sparfloxacin Pharmacokinetics. |
| Author;
KUDO M
(Hirosaki Univ. Hospital, Aomori, Jpn)
SUGAWARA K
(Hirosaki Univ. Hospital, Aomori, Jpn)
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Journal Title;Japanese Journal of Pharmaceutical Health Care and Sciences
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Journal Code:Y0888A
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ISSN:1346-342X
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VOL.30;NO.1;PAGE.8-12(2004)
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| Figure&Table&Reference;FIG.1, TBL.1, REF.24 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The effects of sucralfate, magnesium oxide and sodium ferrous citrate on the pharmacokinetics of sparfloxacin were studied in 6 healthy subjects. According to a four-way crossover design, each subject received the following drug combinations in a random order: (A) a single 200mg dose of sparfloxacin alone; (B) a single 200mg dose of sparfloxacin with a 900mg dose of sucralfate; (C) a single 200mg dose of sparfloxacin with a 1g dose of magnesium oxide; (D) a single 200mg dose of sparfloxacin with a 100mg dose of sodium ferrous citrate. The four regimens were given to subjects in the fasting state. Blood samples were collected over a 24-hour period, and plasma concentrations of sparfloxacin were determined by high-performance liquid chromatography. The area under the curve from 0 to 24 hours (AUC0-24) for sparfloxacin for regimen B was significantly lower (52.9% less, p<0.005) than that for regimen A. However, for regimens C and D, the reductions in AUC0-24 as compared with regimen A were not significant (19.4% and 28.2%, respectively). Also, the peak plasma concentrations (Cmax) of sparfloxacin for regimens B and D were significantly lower (54.7% less, p<0.001 and 31.4% less, p<0.05, respectively) than that for regimen A. However, the Cmax for regimen C was not significantly lower than that for regimen A (22.1% less). These results suggest that aluminum containing drugs should not be given in combination with sparfloxacin. (author abst.) |
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