Separation of Nucleotides by A Zn2+-Cyclen-Conjugated Polymer.
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Accession number;04A0258584
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| Title;Separation of Nucleotides by A Zn2+-Cyclen-Conjugated Polymer. |
| Author;
AOKI SHIN
(Sci. Univ. of Tokyo, Fac. of Pharm. Sci.)
JIKIBA AKIKO
(Hiroshimadai In Ishiyaku)
TAKEDA KEI
(Hiroshimadai In Ishiyaku)
KIMURA EIICHI
(Hiroshima Univ., JPN)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.18th;NO.;PAGE.2-3(2003)
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| Figure&Table&Reference;FIG.1, TBL.1, REF.2 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A new Zn2+-cyclen-conjugated polymer 4 (cyclen = 1,4,7,10-tetraazacyclododecane) was synthesized by copolymerization of Zn2+-(4-vinylbenzyl)cyclen complex (3, ZnL2) with ethyleneglycol dimethacrylate (EGDMA). Contents of zinc(II) ions in the Zn2+-cyclen polymer 4 was determined to be 36-42 .MU.mol/g, utilizing a Zn2+-selective fluorophore. The retention times of deoxyadenosine 5'-monophsophate(5'-dAMP) in high-performance liquid chromatography (HPLC) using 4 as a stationary was found to be larger than those of dA and adenosine 3',5'-cyclic monophosphate (3',5'-cAMP), a fact implying that Zn2+-cyclen-conjugated polymers afford an effective method to detect and separate phosphomonoester anions such as nucleotides. (author abst.) |
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