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Accession number;04A0258588
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| Title;Carbon Dioxide Fixation Mediated upon Zinc-Hydroxo Complex Containing Amino Group: New Proposal of Generation Mechanism of Carboxybiotin. |
| Author;
YAMAGUCHI SHUHEI
(Nagoya Inst. of Tech., Grad. Sch.)
TAKAHASHI TEPPEI
(Nagoya Inst. of Tech., Grad. Sch.)
WADA AKIRA
(Nagoya Inst. of Tech., Grad. Sch.)
FUNAHASHI YASUHIRO
(Nagoya Inst. of Tech., Grad. Sch.)
OZAWA TOMOHIRO
(Nagoya Inst. of Tech., Grad. Sch.)
JITSUKAWA KOICHIRO
(Nagoya Inst. of Tech., Grad. Sch.)
MASUDA HIDEKI
(Nagoya Inst. of Tech., Grad. Sch.)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.18th;NO.;PAGE.10-11(2003)
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| Figure&Table&Reference;FIG.1 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Biotin is a critical cofactor in biotin-dependent carboxylases, and operates fixation of carbon dioxide. In the mechanism of biotin-dependent carboxylases, Mg-H2O (aquo) species bound to urea oxygen is proposed as an active species. In order to understand the participation of such metal species, we prepared a new zinc complex containing tripodal ligand, tris(6-amino-2-pyridylmethyl)amine (TAPA). Reaction of [Zn(tapa)(OH)]ClO4 (1) with CO2 gas in CH3CN gave a CO2-fixed zinc complex 2. The structures of these complexes (1 and 2) were confirmed by the X-ray crystallography and 1H- and 13C-NMR spectra, which indicated that the hydrogen bonding interaction between amino NH and hydroxide oxygen atom stabilized Zn-OH species for complex 1. (author abst.) |
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